gshc2020.com

AI‑designed gene‑editing enzymes expand the CRISPR toolbox

tags:
@ 17/07/2026

AI model designs RNA-guided nucleases that surpass natural nuclease abilities, expanding CRISPR toolbox
RNA-guided nuclease TnpB design strategy with an ESM Inverse Folding (ESM-IF1) model. Credit: Science (2026). DOI: 10.1126/science.aed6123

Scientists have made many advances using traditional CRISPR technology, especially in medicine, but they are now seeking ways to create genuinely new gene-editing enzymes with properties that have not already evolved naturally. A new study, published in Science, describes a new AI-designed synthetic TnpB enzyme, called SynTnpBs, that has outperformed the natural reference enzyme.

Using AI for creative pursuits? Moderation is key | New Scientist

tags:
@ 17/07/2026

There is a “Goldilocks zone” for AI use during creative pursuits

Clare Jackson/Alamy

“Mischa’s parents are hosting their daughter’s engagement party at their country mansion. As she makes a toast, her wine glass slips from her hand to reveal an object embedded in the stem – a tiny memory card. The discovery unravels a decades-old corruption scandal involving her own family, forcing her to choose between justice and loyalty.”

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The hardest part of dementia wasn't losing my mother. It was watching her lose herself.

tags:
@ 17/07/2026

Old photos

The author's mom began to forget her as her dementia progressed.

Courtesy of the author

"Where are all the people?"

My mother, Roberta, was standing in the doorway of the guest bedroom in her house, a bedroom I occupied when I visited. Her short frame was visible in the dark of night, and she wore an almost gossamer nightgown, casting an eerie image of gently floating in place.

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Tooth enamel reveals the origins of African slaves buried on St Helena

tags:
@ 17/07/2026

Tooth enamel reveals the origins of African slaves buried on St Helena
Diverse homelands and early-life displacement among St Helena's liberated Africans. Credit: Science (2026). DOI: 10.1126/science.aeb3661

In the mid-19th century, the remote island of St. Helena, located about 1,200 miles (1,900 kilometers) off the southwestern coast of Africa, became a receiving point for thousands of enslaved Africans rescued from illegal slave ships by the British Royal Navy. Tragically, about 8,000 died shortly after arriving and were buried in unmarked graves in Rupert's Valley.

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