A patient who tore their oesophagus after taking a counterfeit version of an experimental weight loss drug has prompted Australia’s medicines regulator to warn of serious risks of such products.
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The concern relates to retatrutide, a type of drug known as a peptide. Retatrutide has not been approved by the Therapeutic Goods Administration (TGA) or regulators overseas, and it cannot be legally prescribed or sold in Australia.
Peptides are strings of molecules called amino acids that act as chemical messengers in the body, and are involved in a range of functions like hormone activity, digestion, immune defence, and tissue growth. The peptides in retatrutide mimic hunger hormones.
Despite being unapproved, the drug has been widely promoted on social media and promoted for sale on the hidden market, with names including retatrutide, Reta, R-10 and R-20, and they often come in unmarked vials.
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The TGA was alerted after someone experienced such severe and uncontrollable vomiting – after taking what they believed was retatrutide – that they tore their oesophagus, which can be life-threatening. They required treatment in hospital.
The TGA obtained a sample of the product and found it contained a different peptide that also targets hunger, called semaglutide, and no retatrutide.
The amount of semaglutide detected was approximately eight times higher than levels found in approved semaglutide products assessed by the TGA.
The TGA’s chief medical adviser, Prof Robyn Langham, said products being sold online may be fake or counterfeit and could contain ingredients that pose serious risks to health.
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“The biggest risks with unapproved peptide products are not knowing what is in the vial, how much of or even what substance it contains, whether it is sterile, or whether it contains other contaminants or toxins,” she said.
“These risks are particularly concerning for injectable products, where contaminated or non-sterile manufacturing can increase the risk of infection and harmful immune responses including anaphylaxis.”
People who self-inject face additional risks such as incorrect dosing, unsafe injection technique and serious adverse reactions, Langham said.
The Victorian health department issued a similar warning in June, after it was notified of six cases of acute liver toxicity associated with products labelled as retatrutide.
The head of the TGA, Prof Anthony Lawler, said imported and illegal products are “not subject to the same controls over the quality or efficacy of the goods when compared with medicines approved for supply in Australia”.
Australia’s chief medical officer has previously issued a public health warning about unapproved and non-prescribed peptides, after reports of serious adverse effects including liver damage, inflammation and severe allergic reactions. %!s()
The stars of Lanterns explain what the Manhunter was really up to
Photo: John Johnson/HBO Max
Both Hal Jordan (Kyle Chandler) and John Stewart (Aaron Pierre) finally figured out who the Manhunter is at the end of the fourth episode of HBO’s Lanterns, and episode 5, “Lights Out,” deals with the consequences of that revelation. The slow burn mystery gets far more action-packed as chaos descends on Rushville, Nebraska. But the episode still has numerous quieter moments that contextualize the Manhunter’s true motivations. Polygon spoke virtually with the show’s stars to better understand what makes the shapeshifting alien tick.
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Note: This article contains major spoilers for Lanterns episode 5.
Hal meets with Antaan (Paul Ben-Victor), the alien trying to kill the Manhunter for committing genocide on his species. When Hal explains John was compromised by the Manhunter, Antaan asks if they slept together since the Manhunter seduces the strongest member of a given community to bend them to their will. Poorna Jagannathan explains that is exactly why Zoe Macon hooked up with John in the series premiere.
“She sees John as the more powerful Lantern,” Jagannathan says. “The ring is rightfully his. She assesses him to be more dangerous, more of a threat than Hal. Hal she can just take care of.”
Photo: John Johnson/HBO Max
Given that Manhunters can look like anyone, John asks Zoe in episode 5 how she picked her appearance. She delivers a dramatic monologue about how she made herself a woman of color because being an outsider gives her the power to better understand a civilization — and then conquer it. “Adversity makes you stronger in ways comfort never could," Zoe explains. Jagannathan says she deeply relates to that sentiment. Her father was an Indian diplomat, and while she was born in Tunisia, his job also took them to Pakistan, Ireland, and Brazil, where she had to quickly learn new languages and figure out how to fit in.
“Even though I have a family, and a home, and I’ve lived in L.A. for 10 years, the core of me is still an outsider,” Jagannathan says. “I have always grown up with a lot of obstacles, and now as an adult I really appreciate it.”
“It’s a wild relationship”
Image: HBO
While Hal knows Zoe is the Manhunter, he sends Antaan after her husband, William Macon (Garret Dillahunt). That’s an outcome the Macons had prepared for. When Zoe landed in Rushville as the Green Lantern Abin Sur’s captive, William was the strongest protector she could find. Zoe taught William her language and parts of her intimate history with Antaan so he can try to dupe her former lover. William fully accepts that he’s likely going to die to protect Zoe, but he thanks her for the extra time she gave him nonetheless.
“She saved me from cancer, and I’m fitter, happier, and healthier than I’ve ever been,” Dillahunt says. “I think she expands his mind. I’m clearly the first mate in this relationship, and she’s captain. I think that’s something he never thought he would have been comfortable with. He’s used to being the big fish in the little pond, but it’s a wild relationship they have. He’s clearly not totally cool with everything because he likes to give John so much shit about sleeping with Zoe. He’s clearly a little jealous.”
Antaan knows the Manhunter’s tactics from experience. When the Guardians of the Universe decided that their peacekeepers were too brutal, they flipped a switch and exterminated all of the artificial beings. For some reason, Zoe wasn’t affected, so she sought refuge on Antaan’s planet. The two fell in love and even tried to have children together before Zoe wiped out his species.
“She had emotions, wanted to be with him, and wanted to live a life that was beautiful and peaceful,” Jagannathan says. “She's programmed in a very certain way, and she had to fight against her programming, but her programming won. She had to bring her form of justice to this chaos, which resulted in a genocide. Antaan didn't understand that. He didn't understand my core and who I am. He thought I had changed, and I can't change.”
Resisting programming
Photo: John Johnson/HBO Max
While Zoe’s seduction always starts as a tactical move, she also really loves John. He understands her better than Antaan did, which John proves when he points out she must have killed Abin Sur because she was too afraid the Green Lantern would eventually tell the Guardians where she was hiding. Zoe expresses her affection for John after admitting to the murder, saying, “You really see me.” It’s also written on her face in her last moments as she looks back at John before he pulls the trigger and shoots her in the head.
“The thing that will hurt you, you bring the closest to your heart,” Jagannathan says. “She didn’t expect to fall in love with John and see herself in him at all. That last moment when John Stewart actually kills her, she is absolutely blindsided. She assumes everyone works through their programming like she does, and she is blindsided that John doesn’t.”
Zoe understood immediately that John was the more dangerous Green Lantern, but didn’t fully realize why. He proves over and over again that he can resist his “programming.” He consistently ignores orders from both Hal and the Guardians, and then goes on to defy the destiny he’s spent his whole life working toward by turning down the role of Hal Jordan’s replacement. The Guardians couldn’t control the Manhunters, and they couldn’t control John either.
The first five episodes of Lanterns are streaming now on HBO Max. New episodes release Sunday through Oct. 4.%!s()
Singer-songwriter Lucy Dacus has spent nearly the last two years touring her album Forever Is a Feeling. Now, the 31-year-old is ready to close this chapter of her life with a show at the Hollywood Bowl on Sunday night.
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“I’ve found that if I don’t have some degree of ritual or marking of milestones, I get really sad,” Dacus tells The Hollywood Reporter on a recent Zoom from Nashville. “I make plans trying to be respectful of beginnings and endings.” She’s using the show to officially close out this important time in her career.
At the time of this conversation, she’s preparing to head to Seattle for Bumbershoot, a music festival in the city, but her Hollywood Bowl show is still top of mind. Sunday’s show will be different from the rest of the tour, as Dacus will be accompanied by the Hollywood Bowl Orchestra.
Taking the time to go through her discography, with the help of violinist Phoenix Ruziamani, to find the perfect setlist for these specially arranged tracks has given Dacus time to reflect. It’s been helping her feel inspired for the future but first she has to dive into her next big project — absolutely nothing. She explains, “I need to know what it feels like to not do anything for the first time in many years.”
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How did you go about choosing songs for the Hollywood Bowl show. What’s the process with the full orchestra?
Big props to Phoenix Ruziamani, my violinist, who did all the arrangements, because she listened to every song I’ve ever put out and sent me a list of the most exciting ones in terms of [adding] an orchestra. She picked some things that I wouldn’t have thought of at all. “Kissing Lessons,” that’s not even on a record. I don’t play it all the time, and I wouldn’t have thought a punky band song would work great with an orchestra, but it’s one of my favorites. I did choose a few based off of friends and family that are coming, who certain songs matter to them. I thought that would be nice, before I don’t do shows for a while, to play some of these songs for the last time.
When you’re playing those songs, knowing that someone is there, does it feel different?
You know when you re-watch your favorite movie and it didn’t change, but you did? So you see something different. When I play certain songs, I have that feeling. The words are the same, the chords are the same. But especially when there’s people in the audience that know my life and the core of the song, it can make me really remember where it came from and how far I am from that point. That can be very sentimental or really trippy and sometimes emotionally overwhelming, but informative. I’m a sucker for the passing of time in general and for that retrospective feeling.
Does going through your discography like you are for this show make you reflect? Are you feeling inspired by some choices you’ve made in the past?
The retrospective nature can show you maybe lessons you’ve more or less completed, or lessons that you’re still needing to learn or relearn. That can be very humbling. To realize you still don’t know the answer to this question. How stupid of me to think I completed this level of life. Life doesn’t work like that. Certain scenes and parts of my life, I do feel like I need to return to. Other things bore me now, or it just feels not important at the moment to revisit it. I guess, yes, I do feel inspired by this process.
Lucy Dacus performs on Day 2 of Outside Lands Festival at Golden Gate Park on August 8, 2026.
Steve Jennings/Getty Images
What does that look like for you when you find yourself inspired by something? What is your first instinct creatively?
Sometimes I’ll go to the source material, which is my journals, or I’ll go back to Richmond, Virginia, where I’m from and just walk around. I think walking walks I used to walk, passing apartments I used to live in or even seeing people that I’m still friends with, I can just happen into an idea. There are some streets that have ideas floating like coins in a video game, and they’re invisible. Some streets are dense with the coins and other streets are empty. It’s every person’s chance to find those streets and walk them.
How do you continue to find enjoyment with the shows when you’ve been touring the record for a while?
It’s not hard. The magic is there, and I’m just crossing my fingers that it stays. If it ever left, then I’d have to really rethink some things. But every show does feel different. I try to play different songs and not do the same songs in the same order to stay, I guess, alive and not [on] autopilot. The people who are watching weren’t at the last show. It’s the first time for them. Looking into people’s faces really helps me.
Do you feel that throughout your time touring the album your engagement with the audience has changed? Does it feel the same?
I have really good crowds. I feel really spoiled. I like my fans. There’s so many artists that don’t like their fans, and that is so sad. I do think there’s a line that I feel like with Phoebe and Julian and Boygenius, we were definitely trying to set boundaries around how fans treat us. I think that a lot of my fans listened and are not as creepy. But I was saying this to someone recently that some people that I see repeatedly actually will put me at ease because I’m like, “Oh, I know you.” Like, oh, that’s comfortable.
I maybe shouldn’t reveal this publicly, but the band definitely has favorite fans, and they’ll be like, “Did you see this person [near] the front to the left?” Or, “Yeah, I haven’t seen them for a couple months.” You have outliers that can ruin your day, but for the most part, it’s been a nice experience.
That’s wonderful to hear. Do you think that experience with Boygenius, having to set those boundaries, taught you anything?
The real benefit of boundaries is how much time you get back from trying to decide how to act. It’s actually not that there’s less people being weird, it’s that I know how to behave within it more quickly, and I’m not entertaining it. I’ll be like, “nope.” Then it’s not a story that I’m recalling, whereas for a while it felt like, oh, this person waited at my hotel. They put in so much time waiting, they deserve something. It doesn’t take that long to sign something for someone at the airport. But then you realize you don’t want to reward stalking.
Once you know the boundary in yourself, you don’t give any time to that. It doesn’t make every fan interaction abrasive. There are fan interactions that are just nice because a lot of people are normal. I also like musicians, and if I saw someone I liked, I’d be like, “Your work rocks,” and it’d be as simple as that. With the internal boundary making, I’ve reclaimed a lot of time and wavering.
You’re putting a bow on a big chapter of your life with this Hollywood Bowl show. Have you thought about what that’s going to feel like?
I think it’s on purpose because I’ve found that if I don’t have some degree of ritual or marking of milestones, I get really sad. I make plans trying to be respectful of beginnings and endings. That is a huge part of why we even decided to do it. It could be extra sad. There’s a chance that I’m wanting people to come to this and putting all this work into it, and then I’m crying and my throat is closed and it’s not sounding good. That kind of freaks me out. The emotional ultimatum of it is a little overpowering, but I’m also trying to think of it as going to a Cat Power show, and that’s more exciting and less pressure.
Has it been difficult going through new arrangements for the show while you’re still touring? Are you a bit split brained?
Certainly split brain but on one hand, I don’t mind split brain. I like having a lot of irons in the fire. On the other end, I simply need to have no brain. I don’t want to be split between things. I want no things. I want nothing. I need to know what it feels like to not do anything for the first time in many years. That’ll be cool.
What do you think the first thing you’re going to do when you have nothing is going to be?
I was just thinking about this. You start to romanticize doing the dishes and looking at a mess and being like, “Actually, I’ll clean that now.” My brain just automatically puts a hierarchy of like, “Oh, I should do that. Oh, but this person’s expecting this of me.” There’s this backlog of taking care of myself that I really want to do — literally in my home, medically, mentally, emotionally, socially. I have to be a better friend to me than I am to other people for a little bit.
Is that something when you’re really busy, you struggle to get through? You’ve been consistently busy for so long now, do you feel like that is your norm now or do you still find it difficult?
It is my norm to be busy. Honestly, sometimes when I think of this nothingness that’s coming, I get really freaked out because I have so much of my self-worth in what I’m doing and what I’m actively contributing to. I don’t have a lot of self-worth in taking care of myself. I’m always looking outward for things to make me feel good instead of inward. It’ll be huge to see if it’s even possible. Meanwhile, I’m for sure going to pick something up. I’m going to clear some space and then something is going to fill it just because I do think that’s what life is about — following your passions. I feel very happy that I get to do that, so I don’t really want to stop doing it.
Do you have something that’s not music related that you find to be your biggest passion?
Yes.
Do you want to share it?
No, it’s too close to my heart at the moment. %!s()
Traders work on the floor of the New York Stock Exchange (NYSE) on September 09, 2026 in New York City.
Spencer Platt | Getty Images
The 10-year Treasury yield is once again closing in on the psychologically important 5% threshold. For investors, the biggest issue may be what drives it across the line.
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The benchmark yield is hovering around 4.96%, within striking distance of the 5% mark it last touched in October 2023. A climb fueled by resilient economic growth would carry very different implications for stocks and the broader economy than one driven by resurgent inflation, mounting fiscal concerns or stress within the Treasury market itself.
The latest rise in yields stems partly from a supply-demand imbalance as heavy Treasury and corporate issuance competes for investor capital, said Jason Ware, chief investment officer at Albion Financial Group, who added he doesn't expect markets to break simply because the 10-year moves above 5%.
Higher yields aren't necessarily bearish if they're accompanied by healthy growth. Ware pointed to a resilient economy and steady core inflation, arguing that stocks would be more vulnerable to a slowdown in consumer spending or artificial-intelligence investment than to the 10-year crossing an arbitrary threshold.
The 10-year Treasury yield is a key benchmark for borrowing costs across the U.S. economy, influencing everything from mortgages to corporate debt. It is also a crucial reference point for valuing stocks and other financial assets.
Many of the companies driving the equity rally aren't especially sensitive to higher rates, limiting the immediate threat to stocks, according to Niall O'Sullivan, chief investment officer at Marsh Investments. The heavy capital expenditure currently being deployed supports strong economic growth, he said.
However, the 5% level may start to be a problem as investors demand greater compensation for inflation and fiscal risks. Large federal deficits, heavy debt issuance and sticky inflation have all contributed to a rising term premium, while oil's return above $100 a barrel has added another potential source of price pressure.
Treasury Secretary Scott Bessent has sought to contain pressure at the long end, including through an expanded buyback program. But such measures may have limited power against the fundamental forces pushing yields higher.
BMO Capital Markets strategists said a more active buyback program could help limit selling pressure but "fails to address the prevailing fundamental drivers of the upward pressure on 10- and 30-year yields."
Another route to 5% could be more troublesome still: a disorderly move caused by stresses in the Treasury market itself.
George Awad, principal at Gibraltar Capital, has highlighted the large amount of leveraged hedge-fund exposure underpinning the Treasury market, including the cash-futures basis trade. A jump in funding costs, margin requirements or volatility could force leveraged investors to unwind positions simultaneously, potentially amplifying a selloff.
For now, investors appear willing to tolerate higher yields. BMO noted that when the 10-year reached 4.85%, weakness in equities remained modest and the S&P 500 was still up more than 11% for the year.
It remains to be seen whether that continues. %!s()
As he stepped up to the baseline, Alexander Zverev could be forgiven for letting his mind slip back to the last time he served for the US Open title.
Six years ago, the German top seed threw away a two-set lead in a devastating loss to Dominic Thiem, having served for the match in the fifth set.
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This time, instead of his own nerves, it was American Ben Shelton and the majority of the 24,000-strong crowd that stood in Zverev's way.
But this was a different Zverev: a Grand Slam champion now, having won the French Open in June.
Such was his focus that he did not initially realise he had sealed a 6-3 7-6 (7-2) 5-7 6-2 victory.
After firing down another unstoppable serve to win the match, Zverev returned to the baseline ready to start the next point - only to be told by his team the match was over.
"In that moment I was in the zone a lot. I didn't hear noise at all," Zverev said.
"It's funny - tennis teachers always tell you to just play the next point and forget about the score.
"At that moment I forgot about the score and it helped me."
As the realisation sunk in, the 29-year-old broke into a broad and slightly surprised smile before raising his arms above his head.
It was a direct contrast to his defeat by Thiem in 2020, where a tearful Zverev said during the trophy presentation: "I wish one day I can bring the trophy home."
Now, his wish has come true.
"We went 30 years without winning a Grand Slam title and now we've won two in three months," said Zverev.
"2026 is the outcome of all the years that happened before."
Zverev's parents were not there for his previous final at Flushing Meadows, but his father and coach Alexander senior was on the sidelines this time.
As well as paying tribute to his father, Zverev also thanked his mother for her support following his type 1 diabetes diagnosis as a child.
"When doctors tell you that life and sports will be very limited for that child, it takes a very strong mother to say 'my son will be whatever he wants to be'," Zverev said.
"My mother is the most important and strongest person I know."
World number two Zverev has enjoyed his best year on the Tour, reaching the semi-finals at the Australian Open and the final at Wimbledon alongside his French Open and US Open successes.
He has been aided by injuries to Jannik Sinner and Carlos Alcaraz, who swept the majors in the past two seasons, but a strengthened mentality and dedication to fitness has also helped.
"There is no-one as fit as Zverev, he is right up there," former Wimbledon champion Marion Bartoli said on BBC Radio 5 Live.
"You can argue about Alcaraz and Sinner, and Novak [Djokovic] and Rafa [Nadal] when they were in their prime physically, but Zverev is right up there as one of the best athletes to play the sport."
Zverev was taken to five sets in his first two matches, with both finishing in the early hours of the New York morning.
He was two points from defeat in the first round, but rallied, played his way into form and did not drop a set from the third round until the final.
Faced with a partisan crowd against Shelton, Zverev did not buckle. He kept his emotions deliberately in check and, even though he lost the third set, never loosened his grip on the match.
"I'm so admiring of his strength of character and the zen-like state he's been in since the very beginning of the match," said former British number one Annabel Croft.
"The most extraordinary thing - and I don't think I've ever witnessed it - was that he didn't realise he had won.
"It was so bizarre, but it was like he was in a trance-like state while he was playing."
His serve - one of the best on the ATP Tour - was key against Shelton.
He won 39 of 42 points behind his first serve in the first two sets and did not face a break point until the middle of the third.
Shelton broke at the end of the third set to extend the match but the American made little impact in return games from then on, winning only four of 20 receiving points in set four
Victory means he will now have the world number one ranking in his sights - he trails Sinner by 1,810 points with two Masters 1000 events and the season-ending ATP Tour finals to come.
But Zverev is a polarising figure in tennis.
In October 2023, he was given a penalty order and fined 450,000 euros (£392,000) for bodily harm against his ex-partner, with whom he shares a child.
Zverev denied the claims and lodged an objection against the order. A trial in May 2024 was discontinued after a week and there was a separate settlement between Zverev and his ex-girlfriend.
At the time, the court told BBC Sport: "The decision is not a verdict and it is not a decision about guilt or innocence."
Zverev was also accused in October 2020 of physical violence and controlling behaviour by another former girlfriend. He maintained his innocence from the start and there were no legal proceedings. %!s()