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05.08.2026 / 18:30 CET/CEST
Dissemination of a Voting Rights Announcement transmitted by EQS News - a service of EQS Group.
The issuer is solely responsible for the content of this announcement.

Notification of Major Holdings

1. Details of issuer

2. Reason for notification

3. Details of person subject to the notification obligation

Legal entity: Morgan Stanley
City of registered office, country: Wilmington, Delaware, United States of America (USA)

4. Names of shareholder(s)
holding directly 3% or more voting rights, if different from 3.

Morgan Stanley & Co. LLC

5. Date on which threshold was crossed or reached:

29 Jul 2026

6. Total positions

7. Details on total positions
a. Voting rights attached to shares (Sec. 33, 34 WpHG)

b.1. Instruments according to Sec. 38 (1) no. 1 WpHG

b.2. Instruments according to Sec. 38 (1) no. 2 WpHG

8. Information in relation to the person subject to the notification obligation

9. In case of proxy voting according to Sec. 34 para. 3 WpHG
(only in case of attribution of voting rights in accordance with Sec. 34 para. 1 sent. 1 No. 6 WpHG)

Date of general meeting:
Holding total positions after general meeting (6.) after annual general meeting:

10. Other explanatory remarks:

Date

04 Aug 2026

05.08.2026 CET/CEST The EQS Distribution Services include Regulatory Announcements, Financial/Corporate News and Press Releases.
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About Aperam

Aperam is a global player in stainless, electrical and specialty steel and recycling, with customers in over 40 countries. The business is organized in four primary reportable segments: Stainless & Electrical Steel, Services & Solutions, Alloys & Specialties and Recycling & Renewables. Aperam is fully committed to be the leading value creator in the circular economy of infinite, world-changing materials.

Aperam has a flat Stainless and Electrical steel capacity of 2.5 million tonnes in Brazil and Europe and is a leader in Alloys & high value specialty products with presence in France, China, India and the United States. In addition to its industrial network, spread over sixteen production facilities in Brazil, Belgium, France, the United States, India & China, Aperam has a highly integrated distribution, processing and services network and a unique capability to produce low carbon footprint stainless and special steels from biomass, stainless steel scrap and high performance alloys scrap. With Bioenergia and its unique capability to produce charcoal made from its own FSC®-certified forestry and with Aperam Recycling, a global leader in collecting, trading, processing and recycling of stainless steel scrap and high performance alloys, Aperam places sustainability at the heart of its business, helping customers worldwide to excel in the circular economy.

In 2025, Aperam had sales of EUR 6,080 million and shipments of 2.29 million tonnes.

For further information, please refer to our website at www.aperam.com.

Contact

Investor Relations / Roberta de Aguiar Faria: [email protected]
Communication / Ana Escobedo Conover: [email protected]

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For this list, we looked for used trucks in good condition with average mileage (under 100,000 miles), sourcing our average price estimates from listings posted on sites such as CarGurus, Classic.com, and Bring a Trailer as well as consulting Hagerty's valuation tool. What we found is that $35,000 still buys many crazy-quick speed demons with a truck bed, including some of the fastest trucks ever built, such as the Dodge Ram SRT-10, GMC Syclone, and Ford F-150 Lightning Pro — all boasting 0-60 times of under five seconds. We ranked them from slowest to quickest according to their 0-60 mph times.

2019 Ford F-150 Limited: 5.1 seconds

When you think of a fast Ford pickup truck, the insanely rapid Ford F-150 Raptor R is probably the first that comes to mind, with its quoted 3.6-second 0-60 time. But unfortunately, it doesn't exist within our $35,000 budget. What does exist, however, is the 2019 Ford F-150 Limited SuperCrew 4X4, which had enough time to slide down its depreciation curve to become attainable. CarGurus has a 150,000-mile example listed for just under $25,000. The site also offers many other 2019 Ford F-150 Limited SuperCrew models with less than 100,000 miles on the clock for under $35,000. Similarly, Cars.com listings show you can pick one of these up for between $30,000 and $38,000, depending on mileage and condition. Still, this is a big cost saving, seeing as we're talking about a top-of-the-range model that sold for around $70,000 new.

At its heart is a high-output twin-turbo 3.5-liter EcoBoost V6 sourced from the dune-bashing Ford F-150 Raptor. It outputs up to 450 hp and 510-lb-ft of torque to all fours via a 10-speed automatic transmission with manual shifting mode, resulting in a 0-60 time of 5.1 seconds (via Car and Driver). Of course, with this being the Limited trim, you get all that performance without it eroding away some of the truck's nicest bits. First off, every F-150 Limited is a SuperCrew, meaning it comes with four-doors and a 5.5' box. Other features include high-end leather upholstery, Miko suede headliner, heated front and rear seats, cooled and massaging front seats, a heated steering wheel, power-deployable running boards, a twin-panel moonroof, as well as wood interior trim. The 2019 Ford F-150 Limited SuperCrew 4X4 is tow-rated at 12,700 pounds and has a payload capacity of 2,030 pounds.

2004 Ford F-150 SVT Lightning: 5.1 seconds

One of the best pickup trucks for fun on a budget, the playful and exciting Ford SVT Lightning has long been beloved by younger buyers for its looks, performance, and price. Hagerty estimates the average value of examples in good condition at just $33,900, but look around, and you may find them for less. On Edmunds, for example, the performance truck commonly trades from around $30,000, which is interesting considering the SVT Lightning was a low-volume product – only 28,124 units were produced during the entire second generation run that lasted from 1999 to 2004. 

But while Lightnings produced for the 1999 and 2000 model year used a 5.4-liter Triton V8 engine paired with an Eaton supercharger to produce 360 hp and 440 lb-ft of torque, models made for 2001-2004 had a revised version of the engine generating 380 horsepower and 450 lb-ft. The engine is paired to a four-speed automatic which funnels power to the rear wheels. Thanks in part to that uplift in power output, the likes of the 2004 SVT Lightning can sprint from naught to 60 mph in 5.1 seconds in MotorTrend's period testing.

2004 Dodge Ram SRT-10: 4.9 seconds

Chrysler's Street and Racing Technology (SRT) high-performance division pulled off something quite scintillating with the SRT-10, stuffing a 8.3-liter V10 engine borrowed from a Dodge Viper into the 2004 regular cab SRT-10's engine bay. That was enough to make it the production pickup to come with the biggest displacement engine from the factory. Even the Tremec T-56 six-speed manual transmission was lifted from the Viper.

The result? Impressive, as the 2004 Dodge Ram SRT-10 became the world's fastest and most powerful pickup truck at the time, with a top speed of 155 mph and 500 hp and 525 lb-ft on tap. It was quick, too, requiring just 4.9 seconds to go from 0 to 60 mph according to MotorTrend. All that's despite the pickup weighing a hefty 5,100 pounds. Just over 10,000 units were made between 2004 and 2006, and of those, only 3,057 were 2004 model years. However, find one today, and you'll pay from under $34,000, evidenced by this 71,000-mile example listed on Classic.com. As a matter of fact, an average example in good condition is worth around $29,400, per Hagerty's valuation tool.

1991 GMC Syclone: 4.6 seconds

Here's yet another model that's impossible to ignore if you're hunting for a fast pickup truck on a budget. The GMC Syclone was first created in 1991 as a hot version of the GMC Sonoma compact pickup truck, and accordingly, puts stupendous performance in the hands of fun seekers thanks to a 4.3-liter liquid intercooled turbo V6 engine producing 280 hp and 350 lb-ft. That's about 120 more hp and lb-ft than the Sonoma pickup managed with its naturally aspirated 4.3-liter Vortec V6 in 1991. And should you be concerned about performance in slippery conditions, it also features a full-time all-wheel drive system lifted from the GMC Safari van, with a 35% front and 65% rear torque split. As a result, the GMC scoots to 60 mph in just 4.6 seconds. When it was new, the Syclone also famously outran sports cars such as the Ferrari 348ts when Car and Driver undertook a comparison in 1991, and hit the quarter mile in 14.1 seconds at 93 mph compared to the Ferrari's 14.5 seconds at 99 mph.

Not many 1991 Syclones left the factory – roughly 2,995 in total — before GMC started building an SUV version of the truck called the Typhoon for 1992 and 1993. Consequently, there aren't usually very many Syclones for sale at any one time, so the few available ones tend to be quite pricey. However, affordable examples still turn up on the used market — even low mileage ones — now and then. Looking at recent sales on Bring a Trailer, they start from around $20,000, evidenced by this one-family-owned model that sold for just $19,500 in 2025, while another 33k-mile unit went for just $34,600 earlier this year.

2022 Ford F-150 Lightning Pro: 4.2 seconds

As cheap performance pickup trucks go, the 2022 Ford F-150 Lightning Pro is the absolute quickest-accelerating one you can buy under $35,000 used today, with an impressive 4.2-second 0-60 mph sprint as tested by MotorTrend. That comes courtesy of two electric motors fed by a 98-kWh standard-range battery to produce 452 horsepower and 775 lb-ft of torque. Fully charged, the F-150 Lightning Pro can travel up to 230 miles, and 150-kW DC chargers can boost the battery from 15 to 80 percent capacity in under 45 minutes. Edmunds currently shows 79,122- and 87,209-mile examples listed for $34,444 and $34,590, respectively.

While it is pretty significant when you consider the prices of the other vehicles on this list, you'll also be getting a lot in return. Being a 2022 model, the Ford F-150 Lightning Pro is the most recent truck on this list, not to mention the quickest by some distance. That's in addition to a 2,400-watt onboard power station with eight 120-volt outlets, a 12-inch touchscreen display, electronic-locking rear axle, and rear automatic braking. %!s()

"Researchers have long reported that histones with 'off' modifications can exist at genes that are actively expressed; those examples were often treated as oddities or exceptions to the rule," said corresponding author Aseem Ansari, chair of St. Jude's Department of Chemical Biology & Therapeutics. "We are proposing that the barriers can be present, but if the right gene-activating protein is recruited into that environment, the cell treats it more like a road bump than a stop sign."

BRD4 acts as a condensate stepping-stone

In Friedreich's ataxia, the frataxin gene gains hundreds of extra copies of short repeat DNA sequences. These sequences attract machinery that places chemical modifications on histones called methylation marks. A protein called HP1 reads these marks and packs these sections into compact, viscous compartments called condensates that aberrantly silence the gene.

Ansari's team sought to disrupt this process and free the frataxin gene using its synthetic gene regulator, SynGR1. This molecule binds the short repeat DNA sequences and recruits the gene-activating protein BRD4 to the site. However, they discovered a paradox: The gene was being activated, but the methylation marks signaling the repressive "off" state were strengthening.

"To our surprise, the repressive methylation marks and HP1 levels actually increased rather than decreased as expression levels went up," Ansari said. "This made no sense initially, but after years of follow-up work, it became clear that the marks truly were not going away."

The researchers found that BRD4 could enter the repressive HP1 condensate environment and bring gene expression machinery, such as RNA polymerase II, along with it. "We found it is possible to retain repressive methylation marks and still achieve gene expression if there are other factors assisting the polymerase along the way," Ansari said. "With our SynGR1 system, we have provided what amounts to stepping-stones—places where the polymerase can move from one BRD4 molecule to another and continue progressing within this otherwise hostile environment."

The findings suggest that HP1 condensates could be targeted to reactivate genes that have been wrongly switched off, such as in Friedreich's ataxia, or suppress genes that are abnormally active, such as in Huntington's disease. The study also offers a note of caution in making functional statements regarding histone modifications.

"We currently understand perhaps 20 histone modifications—or think we do. Once you begin combining them, the number of possible states becomes enormous, and the complexity becomes overwhelming," Ansari said. "Even with detailed maps, it remains difficult to predict what it will actually take to overcome repression at a given site. Our main takeaway message for this phenomenon is that context really matters."

Publication details

Christopher J. Brandon et al, BRD4 recruitment into HP1 condensates desilences transcription without erasure of repressive chromatin, Nature Cell Biology (2026). DOI: 10.1038/s41556-026-02044-1

Who's behind this story?

Lisa Lock

BA art history, MA material culture. Former museum editor, paramedic, and transplant coordinator. Editing for Science X since 2021. Full profile →

Robert Egan

Bachelor's in mathematical biology, Master's in creative writing. Well-traveled with unique perspectives on science and language. Full profile →

Citation: Restoring the silenced Friedreich's ataxia gene through unconventional means (2026, August 5) retrieved 5 August 2026 from https://phys.org/news/2026-08-silenced-friedreich-ataxia-gene-unconventional.html

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Steve Nesius | Reuters

Parts of a SpaceX rocket reportedly crashed into the moon on Wednesday — a collision analysts say provides a "good metaphor" for the satellite maker's plunging share price.

Elon Musk's SpaceX slumped in morning trade after reporting its first quarterly earnings as a publicly traded company this week. Although revenue soared 92%, investors were unnerved by a sixfold increase in the company's capex to $18.4 billion in the second quarter. The bulk was spent on AI, prompting a rapid retreat from the stock.

Space Exploration Technologies Corp.

The sell-off coincided with the expected impact of part of a two-stage SpaceX Falcon 9 rocket system.

The section was shed from the reusable lower stage following a January 2025 mission involving commercial U.S. and Japanese lunar landers and reportedly struck the moon early on Wednesday. The 4-metric-ton rocket part, which was travelling at more than 5,400 mph, was believed to have unintentionally struck the moon around 2:35 a.m. ET, though the impact has yet to be confirmed.

"Part of a SpaceX rocket crashing into the moon this morning is probably a good metaphor for the share price performance so far," said Chris Beauchamp, chief market analyst at investing and trading platform IG.

The rocket maker's stock was down more than 7% in midday trading, wiping out most of Tuesday's pre-results bounce — and pushing it further below the company's $135 initial public offering price. The sell-off came despite a better-than-expected second-quarter report. Revenue jumped to $7.81 billion, outflanking the $6.93 billion consensus estimates, while losses were narrower than forecast.

"As visual metaphors go, the fact a SpaceX rocket crashed into the moon hours after it had delivered its debut quarterly earnings feels almost too on the nose," said Russ Mould, investment director at AJ Bell.

Further price pressure?

While SpaceX's satellite internet division, Starlink, remains the company's key revenue driver, the group's gigantic AI capex spend is unnerving investors, helping to drag the stock price lower in Wednesday's session.

"This is something the market has taken exception to at many of SpaceX's peers, and the scale of the outlays on artificial intelligence and how much over and above they were on analysts' expectations, were key factors behind the backlash," Mould said.

"A significant difference between SpaceX and some of the other free-spending participants in the AI arms race is that it does not yet generate meaningful levels of cash flow," he said.

In contrast, Musk's comments suggesting that Starlink could successfully expand into terrestrial networks to compete with the likes of T-Mobile, AT&T and Verizon "sparked some nervousness" among those companies, Mould said.

Beauchamp said Starlink, which is currently the only profitable part of SpaceX, is "clearly doing well." But he added that "there needs to be a much more secure path to profitability" if the company's share price is to improve.

The next major test of investor confidence will come Thursday this week, Mould said, when the first investor lockup expiry takes effect, and more than 900 million shares could potentially become available for sale.

"Many of these will be held by insiders whose entry point was significantly below the $135 IPO price, providing an incentive to sell even in light of the recent indifferent showing for the stock," Mould said. %!s()